The challenges of graduate school
Biochemist Paul Doetsch’s recent appearance in a Science magazine feature on laboratory leadership led to a conversation with him about the challenges of graduate school. He emphasized that scientific...
View ArticleResurrecting an ancient receptor to understand a modern drug
To make progress in structural biology, look millions of years into the past. Emory biochemist Eric Ortlund and his colleagues have been taking the approach of “resurrecting” ancient proteins to get...
View ArticleFrom the genetic code to new antibiotics
Biochemist Christine Dunham and her colleagues have a new paper in PNAS illuminating a long-standing puzzle concerning ribosomes, the factories inside cells that produce proteins. Ribosomes are where...
View ArticleOdd couples and persistence
When doctors treat disease-causing bacteria with antibiotics, a few bacteria can survive even if they do not have a resistance gene that defends them from the antibiotic. These rare, slow-growing or...
View ArticleAntibiotic resistance enzyme caught in the act
Resistance to an entire class of antibiotics – aminoglycosides — has the potential to spread to many types of bacteria, according to new biochemistry research. A mobile gene called NpmA was discovered...
View ArticleA new frame of reference — on ribosome frameshifting
It’s a fundamental rule governing how the genetic code works. Ribosomes, the factories that assemble proteins in all types of living cells, read three letters (or nucleotides) of messenger RNA at a...
View ArticleMany colors in the epigenetic palette
Methylation, an epigenetic modification to DNA, can be thought of as a highlighting pen applied to DNA’s text, adding information but not changing the actual letters of the text. Are you still with me...
View ArticleUnexpected mechanism for a longevity lipid
The idea that particular lipid components, such as omega-3 fatty acids, promote health is quite familiar, so the finding that the lipid oleoylethanolamide or OEA extends longevity in the worm C....
View ArticleSUMO wrestling enzyme important in DNA repair
The DNA in our cells is constantly being damaged by heat, radiation and other environmental stresses, and the enzyme systems that repair DNA are critical for life. A particularly toxic form of damage...
View ArticleAncient protein flexibility may drive ‘new’ functions
A mechanism by which stress hormones inhibit the immune system, which appeared to be relatively new in evolution, may actually be hundreds of millions of years old. A protein called the glucocorticoid...
View ArticleUnlocking a liver receptor puzzle
Imagine a key that opens a pin tumbler lock. A very similar key can also fit into the lock, but upside down in comparison to the first key. Biochemist Eric Ortlund and colleagues have obtained...
View ArticleProvocative prions may protect yeast cells from stress
Prions have a notorious reputation. They cause neurodegenerative disease, namely mad cow/Creutzfeld-Jakob disease. And the way these protein particles propagate – getting other proteins to join the...
View ArticleExosomes as potential biomarkers of radiation exposure
Kishore Kumar Jella, PhD Winship Cancer Institute postdoc Kishore Kumar Jella has been invited to speak at the NATO advanced research workshop “BRITE (Biomarkers of Radiation In the Environment):...
View ArticleShaking up thermostable proteins
Imagine a shaker table, where kids can assemble a structure out of LEGO bricks and then subject it to a simulated earthquake. The objective is to design the most stable structure. Biochemists face a...
View ArticleToe in the water for Emory cryo-EM structures
Congratulations to Christine Dunham and colleagues in the Department of Biochemistry for their first cryo-electron microscopy paper, recently published in the journal Structure. The paper solves the...
View ArticleWhat are rods and rings?
This image of mouse embryonic fibroblasts comes from Cara Schiavon, a graduate student in Rick Kahn’s lab in the Department of Biochemistry. It was impressive enough to capture interest from Emory...
View ArticleTracking a frameshift through the ribosome
Ribosomes, the factories that assemble proteins in cells, read three letters of messenger RNA at a time. Occasionally, the ribosome can bend its rules, and read either two or four nucleotides, altering...
View ArticleShape-shifting RNA regulates viral sensor
Congratulations to Emory biochemists Brenda Calderon and Graeme Conn. Their recent Journal of Biological Chemistry paper on a shape-shfting RNA was selected as an Editor’s Pick and cited as a “joy to...
View ArticleBiochemists grab slippery target: LRH-1
To fight fat, scientists had to figure out how to pin down a greasy, slippery target. Researchers at Emory University and Baylor College of Medicine have identified compounds that potently activate...
View ArticleTracking how steroid hormone receptor proteins evolved
When thinking about the evolution of female and male, consider that the first steroid receptor proteins, which emerged about 550 million years ago, were responsive to estrogen. The ancestor of other...
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